What Lowers Your Blood Cholesterol? Although some nutrients, including some fats, raise the blood cholesterol level, some other nutrients have no effect on it and still others reduce it. Nutrients that help reduce blood cholesterol levels include polyunsaturated fat and monounsaturated fat. Carbohydrates can help replace fat in the diet. By substituting these nutrients for foods containing saturated fat and cholesterol, you can help decrease your blood cholesterol level.